Clinical and genetic analysis of metastatic prostate cancer to the central nervous system: a single-institution retrospective experience

Prostate cancer (PC) is the second most common malignancy in men after skin cancer. There will be an estimated 268,490 new cases in the United States in 2022.1 The most common pattern of metastasis is to the bone, liver, lung, and lymph nodes, while brain metastasis is very rare. From large single-institution reviews, the incidence of PC metastasizing to the brain parenchyma has been under 1%.2, 3 The SEER database analyzed from 2010-2015 showed a similar incidence rate of 0.6% of PC patients with brain metastases (BMs).